发明申请
US20050233344A1 RNA interference mediated inhibition of platelet derived growth factor (PDGF) and platelet derived growth factor receptor (PDGFR) gene expression using short interfering nucleic acid (siNA)
审中-公开
使用短干扰核酸（siNA）的RNA干扰介导的血小板衍生生长因子（PDGF）和血小板衍生生长因子受体（PDGFR）基因表达的抑制
- 专利标题： RNA interference mediated inhibition of platelet derived growth factor (PDGF) and platelet derived growth factor receptor (PDGFR) gene expression using short interfering nucleic acid (siNA)
- 专利标题（中）： 使用短干扰核酸（siNA）的RNA干扰介导的血小板衍生生长因子（PDGF）和血小板衍生生长因子受体（PDGFR）基因表达的抑制
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申请号： US10923270申请日： 2004-08-20
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公开(公告)号： US20050233344A1公开(公告)日： 2005-10-20
- 发明人: James McSwiggen , Leonid Beigelman , Bharat Chowrira
- 申请人： James McSwiggen , Leonid Beigelman , Bharat Chowrira
- 申请人地址： US CO Boulder 80301
- 专利权人： Sirna Therapeutics, Inc.
- 当前专利权人： Sirna Therapeutics, Inc.
- 当前专利权人地址： US CO Boulder 80301
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K47/48 ; C07H21/02 ; C12N15/11 ; C12N15/113 ; C12N15/115 ; C12N15/87 ; A61K48/00 ; C12Q1/68
摘要：
This invention relates to compounds, compositions, and methods useful for modulating platelet derived growth factor (PDGF) and/or platelet derived growth factor receptor (PDGFr) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of platelet derived growth factor (PDGF) and/or platelet derived growth factor receptor (PDGFr) gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of platelet derived growth factor (PDGF) and/or platelet derived growth factor receptor (PDGFr) genes, such as PDGF and/or PDGFr.
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