Alternative designs, materials, and methods of making and using catheter manifolds. Some embodiments are related to a balloon catheter including a catheter shaft having a proximal portion and a distal portion. The shaft includes an outer tubular member defining a lumen and having a proximal end and a distal end. The shaft also includes an inner tubular member defining a lumen and having a proximal end and a distal end. The inner tubular member is disposed at least partially within the outer tubular member such that the proximal end of the inner tubular member extends proximally from the proximal end of the outer tubular member. A catheter manifold is molded about a portion of the outer tubular member and a portion of the inner tubular member, and a balloon assembly attached to the distal portion of the shaft such that the balloon assembly is in fluid communication with at least one of the lumens.