发明申请
US20050239748A1 Pharmaceutical salts of 3-O-(3',3'-dimethylsuccinyl) betulinic acid
审中-公开
3-O-（3'，3'-二甲基琥珀酰基）桦木酸的药物盐
- 专利标题： Pharmaceutical salts of 3-O-(3',3'-dimethylsuccinyl) betulinic acid
- 专利标题（中）： 3-O-（3'，3'-二甲基琥珀酰基）桦木酸的药物盐
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申请号： US11081802申请日： 2005-03-17
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公开(公告)号： US20050239748A1公开(公告)日： 2005-10-27
- 发明人: Martin Power , David Martin
- 申请人： Martin Power , David Martin
- 申请人地址： US MD Gaithersburg
- 专利权人： Panacos Pharmaceuticals, Inc.
- 当前专利权人： Panacos Pharmaceuticals, Inc.
- 当前专利权人地址： US MD Gaithersburg
- 主分类号： A61K31/56
- IPC分类号： A61K31/56 ; A61K31/7008 ; A61K31/724 ; C07J53/00 ; C08B35/00
摘要：
Salts of 3-O-(3′,3′-dimethylsuccinyl)Betulinic acid (DSB) are disclosed. Particularly, the preparation, pharmaceutical evaluation, and in vivo bioavailability evaluation of N-methyl-D-glucamine and alkali metal salt forms of DSB are disclosed. Pharmaceutical compositions including these salt forms are used in methods of treating HIV and related diseases. Methods of making the salts of DSB and the pharmaceutical compositions are also provided.
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