发明申请
US20050239856A1 Method for prophylaxis and treatment of diabetic complications with 4{alpha-hydroxy-2-methyl-5-(1-imidazolyl)benzyl}-3,5-dimethylbenzoic acid and derivatives
审中-公开
用4种{α-羟基-2-甲基-5-（1-咪唑基）苄基} -3,5-二甲基苯甲酸及其衍生物预防和治疗糖尿病并发症的方法
- 专利标题： Method for prophylaxis and treatment of diabetic complications with 4{alpha-hydroxy-2-methyl-5-(1-imidazolyl)benzyl}-3,5-dimethylbenzoic acid and derivatives
- 专利标题（中）： 用4种{α-羟基-2-甲基-5-（1-咪唑基）苄基} -3,5-二甲基苯甲酸及其衍生物预防和治疗糖尿病并发症的方法
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申请号： US11152376申请日： 2005-06-15
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公开(公告)号： US20050239856A1公开(公告)日： 2005-10-27
- 发明人: Yoshiharu Hayashi , Nobuharu Goto
- 申请人： Yoshiharu Hayashi , Nobuharu Goto
- 优先权： JP340161/1995 19951227
- 主分类号： A61K31/415
- IPC分类号： A61K31/415 ; A61K31/4164 ; A61P3/10 ; C07D233/54 ; C07D233/60 ; C07D521/00
摘要：
The present invention relates to an agent for the prophylaxis and treatment of diabetic complications comprising, as an active ingredient, 4-[α-hydroxy-2-methyl-5(1-imidazolyl)benzyl]-3,5-dimethylbenzoic acid, an optically active compound thereof or a pharmaceutically acceptable salt thereof. The present invention further relates to a method for the prophylaxis and treatment of diabetic complications comprising administering an effective amount of this compound. The medicament of the present invention is useful for the prophylaxis and treatment of diabetic complications, namely, diabetic neuropathy, nephropathy, ophthalmopathy, arteriosclerosis and the like. The action of the drug is long-lasting for very small doses and a single administration a day is sufficient.
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