发明申请
US20050239859A2 NOVEL MEDICAL USES OF 4,5-DIHYDRO-1H-PYRAZOLE DERIVATIVES HAVING CB1- ANTAGONISTIC ACTIVITY
审中-公开
具有CB1-拮抗活性的4,5-二氢-1H-吡唑衍生物的新医学用途
- 专利标题： NOVEL MEDICAL USES OF 4,5-DIHYDRO-1H-PYRAZOLE DERIVATIVES HAVING CB1- ANTAGONISTIC ACTIVITY
- 专利标题（中）： 具有CB1-拮抗活性的4,5-二氢-1H-吡唑衍生物的新医学用途
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申请号： US10929377申请日： 2004-08-31
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公开(公告)号： US20050239859A2公开(公告)日： 2005-10-27
- 发明人: Jochen Antel , Gunter Krause , Josephus Lange , Cornelis Kruse , Peter-Colin Gregory , Cathaline Den Besten
- 申请人： Jochen Antel , Gunter Krause , Josephus Lange , Cornelis Kruse , Peter-Colin Gregory , Cathaline Den Besten
- 申请人地址： DE Hanover 30173
- 专利权人： Solvay Pharmaceuticals GmbH
- 当前专利权人： Solvay Pharmaceuticals GmbH
- 当前专利权人地址： DE Hanover 30173
- 主分类号： A61K31/415
- IPC分类号： A61K31/415
摘要：
Abstract of the DisclosureThe present invention relates to a novel medical use of 4,5-dihydro-1H-pyrazole compounds which are potent antagonists of the cannabis CB1-receptor. Said compounds are particularly suitable in the manufacture of medicaments for the treatment and/or prophylaxis of CB1 receptor related diseases in juvenile patients and/or for the treatment and/or prophylaxis of drug induced obesity in juvenile as well as in adolescent patients. The compounds have the general formula (I) wherein the group Bb represents sulfonyl or carbonyl, and the substituents R, R1, R2 and R3, and the group Aa are defined as shown in the description.