发明申请
- 专利标题: Process for producing crystalline nucleus and method of screening crystallization conditions
- 专利标题(中): 生产晶核的方法和筛选结晶条件的方法
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申请号: US10525809申请日: 2003-08-25
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公开(公告)号: US20050241568A1公开(公告)日: 2005-11-03
- 发明人: Takatomo Sasaki , Yusuke Mori , Masashi Yoshimura , Hiroaki Adachi , Hiroshi Masuhara , Youichiroh Hosokawa , Kazufumi Takano
- 申请人: Takatomo Sasaki , Yusuke Mori , Masashi Yoshimura , Hiroaki Adachi , Hiroshi Masuhara , Youichiroh Hosokawa , Kazufumi Takano
- 申请人地址: JP Osaka-shi, Osaka 540-0029
- 专利权人: Osaka Industrial Promotion Organization
- 当前专利权人: Osaka Industrial Promotion Organization
- 当前专利权人地址: JP Osaka-shi, Osaka 540-0029
- 优先权: JP2002-245700 20020826; JP2002-382617 20021227; JP2003-86561 20030326; JP2003-273685 20030711
- 国际申请: PCT/JP03/10681 WO 20030825
- 主分类号: C30B7/00
- IPC分类号: C30B7/00 ; C30B9/00
摘要:
The present invention relates to a process for producing high-quality crystals of protein or organic substances easily and efficiently. A solution of protein or an organic substance is prepared and then is cooled slowly to be supersaturated to a low degree. This supersaturated solution is irradiated with a femtosecond laser 10. A local explosion phenomenon occurs at the focal point of the laser and thereby a crystalline nucleus is generated. A high-quality crystal is obtained when a crystal is grown on the crystalline nucleus over a long period of time. The femtosecond laser to be used herein can be a titanium:sapphire laser having a wavelength of 800 nm, a duration of 120 fs, a frequency of 1 kHz, and an output of 400 mW.