发明申请
- 专利标题： Method of screening insulin resistance inproving drug
- 专利标题（中）： 筛查胰岛素抵抗药物的方法
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申请号： US10519447申请日： 2003-07-01
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公开(公告)号： US20050244829A1公开(公告)日： 2005-11-03
- 发明人: Makoto Ogino , Hideki Endoh
- 申请人： Makoto Ogino , Hideki Endoh
- 优先权： JP2002-193814 20020702
- 国际申请： PCT/JP03/08367 WO 20030701
- 主分类号： A61P3/08
- IPC分类号： A61P3/08 ; C07K14/47 ; G01N33/50 ; C12Q1/68 ; C12N1/18 ; C12Q1/66
摘要：
A method for identifying and screening a novel substance promoting the transcription induction activity of PPARγ and improving insulin resistance by promoting the interaction between PPAR promoting the transcription induction activity of PPARγ and p68 RNA helicase and/or promoting the expression of p68RNA helicase is disclosed. The method is a new type method for screening an agent for improving insulin resistance by promoting the transcription induction activity of PPARγ which is different from the conventional PPAR agonist. Furthermore, the method for producing a pharmaceutical composition for improving insulin resistance which comprises the substance obtainable by the above method for screening as an active ingredient is disclosed.