发明申请
- 专利标题： Identification of ligands by selective amplification of cells transfected with receptors
- 专利标题（中）： 通过用受体转染的细胞的选择性扩增鉴定配体
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申请号： US11083173申请日： 2005-03-16
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公开(公告)号： US20050244862A1公开(公告)日： 2005-11-03
- 发明人: Mark Brann
- 申请人： Mark Brann
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C12N15/85 ; C12Q1/68
摘要：
The invention is directed to a method for identifying substances acting as ligands for transfected receptors by using transfected markers to measure receptor/ligand interactions. The present invention also relates to a method of identifying compounds which act as inverse agonists of the 5-HT2A receptor, the method comprising contacting a constitutively active 5-HT2A receptor with at least one test compound and determining any decrease in the amount of basal activity of the receptor so as to identify a test compound which is an inverse agonist of the 5-HT2A receptor. Such inverse agonists may be used in the treatment of schizophrenia and related psychoses.
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