发明申请
US20050245472A1 Engineered rnai adenovirus silencing expression (erase) of dna reair proteins
审中-公开
dna reair蛋白的工程化rnai腺病毒沉默表达（擦除）
- 专利标题： Engineered rnai adenovirus silencing expression (erase) of dna reair proteins
- 专利标题（中）： dna reair蛋白的工程化rnai腺病毒沉默表达（擦除）
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申请号： US10534010申请日： 2003-11-12
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公开(公告)号： US20050245472A1公开(公告)日： 2005-11-03
- 发明人: Theodore DeWeese , Spencer Collins , William Nelson
- 申请人： Theodore DeWeese , Spencer Collins , William Nelson
- 申请人地址： US MD Baltimore 21218
- 专利权人： The Johns Hopkins University
- 当前专利权人： The Johns Hopkins University
- 当前专利权人地址： US MD Baltimore 21218
- 国际申请： PCT/US03/36367 WO 20031112
- 主分类号： A61K31/137
- IPC分类号： A61K31/137 ; A61K31/28 ; A61K31/396 ; A61K31/66 ; A61K38/00 ; A61K48/00 ; C12N15/11 ; C12N15/113 ; C12N15/861
摘要：
The present invention relates to compositions and methods for killing cancer cells and treating subjects having cancer comprising administering small inhibitory RNAs (siRNA) specific for DNA repair proteins in conjunction with administration of conventional DNA-damaging agents such as radiation and chemotherapeutic agents.