发明申请
US20050249671A9 Neutrokine-alpha conjugate, neutrokine-alpha complex, and uses thereof
审中-公开
中性粒细胞α偶联物，中性粒细胞α复合物及其应用
- 专利标题： Neutrokine-alpha conjugate, neutrokine-alpha complex, and uses thereof
- 专利标题（中）： 中性粒细胞α偶联物，中性粒细胞α复合物及其应用
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申请号： US10742634申请日： 2003-12-22
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公开(公告)号： US20050249671A9公开(公告)日： 2005-11-10
- 发明人: David Parmelee , Ren-Hwa Yeh , Olga Galperina , David Hilbert , Craig Rosen
- 申请人： David Parmelee , Ren-Hwa Yeh , Olga Galperina , David Hilbert , Craig Rosen
- 主分类号： A61K47/48
- IPC分类号： A61K47/48 ; C07K14/52 ; A61K49/00 ; C07K14/525
摘要：
The present invention is directed to a Neutrokine-alpha conjugate, wherein said Neutrokine-alpha conjugate comprises a Neutrokine-alpha protein and a chelator. The present invention is also directed to a Neutrokine-alpha complex, wherein said Neutrokine-alpha complex comprises a Neutrokine-alpha conjugate and a metal ion wherein said metal ion is noncovalently associated with the chelator of said conjugate. The present invention is further directed to compositions, specifically pharmaceutical and diagnostic compositions, comprising a Neutrokine-alpha conjugate or complex as described herein. Therapeutic and diagnostic uses of said conjugate, complex, and compositions are described.