发明申请
- 专利标题： Substituted indoles and their use as integrin antagonists
- 专利标题（中）： 取代的吲哚及其作为整联蛋白拮抗剂的用途
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申请号： US11005294申请日： 2004-12-06
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公开(公告)号： US20050250771A1公开(公告)日： 2005-11-10
- 发明人: Tianbo Lu , Bruce Tomczuk , Louis LaFrance , Thomas Markotan , Juan Marugan Sanchez , Victor Marder , David U'Prichard , Beth Anaclerio , Zihong Guo , Wenzi Pan , Kristi Leonard
- 申请人： Tianbo Lu , Bruce Tomczuk , Louis LaFrance , Thomas Markotan , Juan Marugan Sanchez , Victor Marder , David U'Prichard , Beth Anaclerio , Zihong Guo , Wenzi Pan , Kristi Leonard
- 专利权人： 3-Dimensional Pharmaceuticals, Inc.
- 当前专利权人： 3-Dimensional Pharmaceuticals, Inc.
- 主分类号： A61K31/404
- IPC分类号： A61K31/404 ; A61K31/4375 ; A61K31/4439 ; A61K31/4709 ; A61K31/5383 ; A61P3/06 ; A61P3/10 ; A61P7/06 ; A61P9/00 ; A61P9/10 ; A61P19/10 ; A61P25/00 ; A61P25/04 ; A61P25/08 ; A61P25/18 ; A61P25/22 ; A61P27/02 ; A61P29/00 ; A61P35/00 ; A61P43/00 ; C07D209/08 ; C07D213/74 ; C07D401/12 ; C07D401/14 ; C07D403/12 ; C07D471/04 ; C07D498/04 ; A61K31/538 ; A61K31/405 ; A61K31/4745 ; A61K31/506 ; C07D413/02 ; C07D43/02
摘要：
The present invention relates to novel substituted indole compounds that are antagonists of alpha V (αv) integrins, for example αvβ3 and αvβ5 integrins, their pharmaceutically acceptable salts, and pharmaceutical compositions thereof. The compounds may be used in the treatment of pathological conditions mediated by αvβ3 and αvβ5 integrins, including such conditions as tumor growth, metastasis, restenosis, osteoporosis, inflammation, macular degeneration, diabetic retinopathy, and rheumatoid arthritis. The compounds have the general formula: where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, , R12, R13, R14, D, X, W, a, m, n, i, j, k and v are defined herein.
公开/授权文献
- US07241789B2 Substituted indoles and their use as integrin antagonists 公开/授权日：2007-07-10
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