发明申请
- 专利标题： Stable pharmaceutical compsition containing factor VIII
- 专利标题（中）： 稳定的药物成分含有因子VIII
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申请号： US10507956申请日： 2003-03-26
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公开(公告)号： US20050256038A1公开(公告)日： 2005-11-17
- 发明人: Mary White , Paul Webb
- 申请人： Mary White , Paul Webb
- 优先权： GB0207092.8 20020326
- 国际申请： PCT/GB03/01297 WO 20030326
- 主分类号： A61K31/495
- IPC分类号： A61K31/495 ; A61K9/19 ; A61K38/37 ; A61K38/43 ; A61K47/02 ; A61K47/04 ; A61K47/12 ; A61K47/18 ; A61K47/26 ; A61K47/34 ; A61K47/36 ; A61P7/04 ; A61K31/7012
摘要：
The invention relates to a stable solid pharmaceutical composition comprising factor VIII. Such a composition is devoid of amino acids and comprises: (a) factor VIII; (b) a surfactant; (c) calcium chloride; (d) sucrose; (e) sodium chloride; (f) trisodium citrate; and (g) a buffer devoid of amino acids; and has a pH from 6 to 8 prior to lyophilisation and after reconstitution in water for injection. The invention also relates to the liquid pharmaceutical composition obtainable after dilution of said stable solid pharmaceutical composition with sterile water optionally containing sodium chloride.
公开/授权文献
- US07790680B2 Stable pharmaceutical composition containing factor VIII 公开/授权日：2010-09-07
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