发明申请
- 专利标题: Thienopyridinone compounds and methods of treatment
- 专利标题(中): 噻吩并吡啶酮化合物及其处理方法
-
申请号: US10955434申请日: 2004-09-30
-
公开(公告)号: US20050256153A1公开(公告)日: 2005-11-17
- 发明人: Dale Dhanoa , Oren Becker , Silvia Noiman , Pradyumna Mohanty , Dongli Chen , Mercedes Lobera , Laurence Wu , Yael Marantz , Boaz Inbal , Alexander Heifetz , Shay Bar-Haim , Sharon Shacham
- 申请人: Dale Dhanoa , Oren Becker , Silvia Noiman , Pradyumna Mohanty , Dongli Chen , Mercedes Lobera , Laurence Wu , Yael Marantz , Boaz Inbal , Alexander Heifetz , Shay Bar-Haim , Sharon Shacham
- 主分类号: A61K31/4743
- IPC分类号: A61K31/4743 ; C07D495/04 ; C07D498/02
摘要:
The invention relates to 5-HT receptor agonists and partial agonists. Novel thienopyridinone compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include Alzheimer's disease, cognition disorders, irritable bowel syndrome, nausea, emesis, vomiting, prokinesia, gastroesophageal reflux disease, nonulcer dyspepsia, depression, anxiety, urinary incontinence, migraine, arrhythmia, atrial fibrillation, ischemic stroke, gastritis, gastric emptying disorders, feeding disorders, gastrointestinal disorders, constipation, erectile dysfunction, and respiratory depression. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.
公开/授权文献
- US07488736B2 Thienopyridinone compounds and methods of treatment 公开/授权日:2009-02-10