发明申请
- 专利标题： Combination therapy with CHK1 inhibitors
- 专利标题（中）： 与CHK1抑制剂组合治疗
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申请号： US11041191申请日： 2005-01-21
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公开(公告)号： US20050256157A1公开(公告)日： 2005-11-17
- 发明人: Thomas Gesner , Paul Barsanti , Stephen Harrison , Zhi-Jie Ni , Nathan Brammeier , Yasheen Zhou , Vincent Le
- 申请人： Thomas Gesner , Paul Barsanti , Stephen Harrison , Zhi-Jie Ni , Nathan Brammeier , Yasheen Zhou , Vincent Le
- 专利权人： CHIRON CORPORATION
- 当前专利权人： CHIRON CORPORATION
- 主分类号： A61K31/4709
- IPC分类号： A61K31/4709
摘要：
Compounds of Structure I, and salts, tautomers, stereoisomers, and mixtures thereof may be used in methods of inhibiting checkpoint kinase 1 in subjects, in methods for inducing cell cycle progression, and in methods for increasing apoptosis in cells. Such compounds may be used to prepare pharmaceutical compositions and may be used in conjunction with DNA damaging agents.