发明申请
US20050260132A1 Monoclonal antibodies directed to receptor protein tyrosine phosphatase zeta
审中-公开
针对受体蛋白酪氨酸磷酸酶ζ的单克隆抗体
- 专利标题： Monoclonal antibodies directed to receptor protein tyrosine phosphatase zeta
- 专利标题（中）： 针对受体蛋白酪氨酸磷酸酶ζ的单克隆抗体
-
申请号： US11097728申请日： 2005-03-31
-
公开(公告)号： US20050260132A1公开(公告)日： 2005-11-24
- 发明人: Daniel Chin , Erik Foehr , Sabine Mueller , Thorsten Melcher
- 申请人： Daniel Chin , Erik Foehr , Sabine Mueller , Thorsten Melcher
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K47/48 ; A61K51/00 ; C07K16/28 ; C07K16/30
摘要：
The present invention relates to a method of inhibiting growth of tumor cells which overexpress a receptor protein tyrosine phosphatase zeta (PTPζ) by treatment of the cells with antibodies which recognize PTPζ and/or inhibit PTPζ function. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention. The present invention also provides novel splice variants of protein PTPζ, PTPζ SM1 and PTPζ SM2. Nucleic acid probes specific for the spliced mRNA encoding these variants and affinity reagents specific for the novel proteins are also provided.
信息查询
