A multi-lumen catheter comprising a loop-like structure at the distal portion of the catheter is disclosed herein. In one variation, the loop-tip catheter comprises a dual lumen catheter and a loop-like structure at the distal end of the catheter. The loop-like structure includes at least one lumen, which is in fluid communication with at lease one of the two lumens in the dual lumen catheter. One or more ports are provided on the loop-like structure for accessing the lumens within the loop. In another variation, the loop-tip catheter is configured with an arterial inlet positioned on an inner surface of the loop, while a venous outlet is positioned on an outer surface of the loop. Methods for making and using variations of the loop-tip catheter are also disclosed herein.