发明申请
- 专利标题： Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
- 专利标题（中）： 延长寿命并增加细胞和生物体的抗应力的方法和组合物
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申请号： US11053185申请日： 2005-02-08
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公开(公告)号： US20050267023A1公开(公告)日： 2005-12-01
- 发明人: David Sinclair , Kevin Bitterman
- 申请人： David Sinclair , Kevin Bitterman
- 主分类号： A61K31/455
- IPC分类号： A61K31/455 ; A61K31/7076
摘要：
The invention provides methods and compositions for modulating the life span of eukaryotic and prokaryotic cells and for protecting cells against certain stresses, e.g., heatshock. One method comprises modulating the flux of the NAD+ salvage pathway in the cell, e.g., by modulating the level or activity of one or more proteins selected from the group consisting of NPT1, PNC1, NMA1 and NMA2. Another method comprises modulating the level of nicotinamide in the cell.
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