发明申请
US20050272652A1 Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity
审中-公开
用于治疗糖尿病，胰岛素抵抗和肥胖的GIP的肽类似物
- 专利标题： Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity
- 专利标题（中）： 用于治疗糖尿病，胰岛素抵抗和肥胖的GIP的肽类似物
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申请号： US11090787申请日： 2005-03-25
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公开(公告)号： US20050272652A1公开(公告)日： 2005-12-08
- 发明人: Victor Gault , Finbarr O'Harte , Nigel Irwin , Patrick Harriott , Peter Flatt
- 申请人： Victor Gault , Finbarr O'Harte , Nigel Irwin , Patrick Harriott , Peter Flatt
- 优先权： GBGB0404124.0 20040225; GBGB9907216.7 19990329; GBGB9917565.5 19990727
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K38/22 ; C07K14/575
摘要：
The present invention provides peptide analogues which are antagonists of gastric inhibitory peptide (GIP). The peptides, based on GIP 1-42 include substitutions and/or modifications which have enhanced resistance to degradation by the enzyme dipeptidyl peptidase IV (DPP IV). The invention also provides a process of N terminally modifying GIP and the use of the peptide analogues for treatment of diabetes.
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