发明申请
US20050272669A1 Pyrazole derivatives, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof
有权
吡唑衍生物,含有该吡唑衍生物的药物组合物,其医药用途及其生产用中间体
- 专利标题: Pyrazole derivatives, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof
- 专利标题(中): 吡唑衍生物,含有该吡唑衍生物的药物组合物,其医药用途及其生产用中间体
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申请号: US10525197申请日: 2003-08-21
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公开(公告)号: US20050272669A1公开(公告)日: 2005-12-08
- 发明人: Nobuhiko Fushimi , Kazuo Shimizu , Shigeru Yonekubo , Hirotaka Teranishi , Masaki Tomae , Masayuki Isaji
- 申请人: Nobuhiko Fushimi , Kazuo Shimizu , Shigeru Yonekubo , Hirotaka Teranishi , Masaki Tomae , Masayuki Isaji
- 优先权: JP2002-244381 20020823; JP2002-324076 20021107
- 国际申请: PCT/JP03/10551 WO 20030821
- 主分类号: A61K31/00
- IPC分类号: A61K31/00 ; A61K31/10 ; A61K31/205 ; A61K31/37 ; A61K31/4166 ; A61K31/7056 ; A61K31/7072 ; A61K31/737 ; A61K38/18 ; A61K38/28 ; A61K45/00 ; A61K45/06 ; A61P3/04 ; A61P3/06 ; A61P3/10 ; A61P5/48 ; A61P7/10 ; A61P9/04 ; A61P9/10 ; A61P9/12 ; A61P19/06 ; A61P43/00 ; C07H17/02 ; A61K31/7052
摘要:
The present invention provides pyrazole derivatives represented by the general formula: wherein R1 represents H, an optionally substituted C1-6 alkyl group etc.; one of Q and T represents a group represented by the general formula: or a group represented by the general formula: while the other represents an optionally substituted C1-6 alkyl group etc.; R2 represents H, a halogen atom, OH, an optionally substituted C1-6 alkyl group etc.; X represents a single bond, O or S; Y represents an optionally substituted C1-6 alkylene group etc.; Z represents —RB, —CORC etc. in which RB represents an optionally substituted C1-6 alkyl group etc.; and RC represents an optionally substituted C1-6 alkyl group etc.; R4 represents H, an optionally substituted C1-6 alkyl group etc.; and R3, R5 and R6 represent H, a halogen atom etc., pharmaceutically acceptable salts thereof or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT1 and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, impaired glucose tolerance, impaired fasting glycemia, diabetic complications or obesity, and a disease associated with the increase of blood galactose level such as galactosemia, and pharmaceutical compositions comprising the same, pharmaceutical uses thereof, and intermediates for production thereof.
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