发明申请
- 专利标题: Function of autophagy genes in cell death
- 专利标题(中): 自噬基因在细胞死亡中的功能
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申请号: US11119569申请日: 2005-05-02
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公开(公告)号: US20050276809A1公开(公告)日: 2005-12-15
- 发明人: Eric Baehrecke , Ajjai Alva , Michael Lenardo , Yu Li
- 申请人: Eric Baehrecke , Ajjai Alva , Michael Lenardo , Yu Li
- 主分类号: A61K38/05
- IPC分类号: A61K38/05 ; A61K38/06 ; A61K39/395 ; A61K48/00 ; C12N15/113
摘要:
The present invention relates to a new molecular pathway in which activation of the receptor-interacting protein (RIP, a serine-threonine kinase) and Jun N-terminal kinase induce cell death with the morphology of autophagy. Further, autophagic death is induced by caspase 8 inhibition and expression of the mammalian genes ATG7 and beclin.
公开/授权文献
- US07838645B2 Function of autophagy genes in cell death 公开/授权日:2010-11-23
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