Invention Application
- Patent Title: Pharmaceutical compositions comprising cyclosporins
- Patent Title (中): 包含环孢菌素的药物组合物
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Application No.: US10865638Application Date: 2004-06-09
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Publication No.: US20050277584A1Publication Date: 2005-12-15
- Inventor: Walter Tien , Richard Graham , James Chang
- Applicant: Walter Tien , Richard Graham , James Chang
- Applicant Address: US CA Irvine
- Assignee: ALLERGAN, INC.
- Current Assignee: ALLERGAN, INC.
- Current Assignee Address: US CA Irvine
- Main IPC: A61K9/00
- IPC: A61K9/00 ; A61K9/08 ; A61K31/355 ; A61K38/13 ; A61K47/22

Abstract:
A liquid comprising a therapeutically effective concentration of a cyclosporin and a vitamin E tocopherol polyethylene glycol succinate, wherein said liquid is an aqueous solution, and wherein no hydrophilic organic solvent is present at a concentration greater than half of that of the cyclosporin is also disclosed herein. A composition comprising a therapeutically effective concentration of cyclosporin A and an effective amount of a vitamin E tocopherol polyethylene glycol succinate, wherein said composition is an aqueous liquid solution which is intended for ophthalmic use, and wherein no hydrophilic organic solvent is present at a mass concentration greater than or equal to that of the cyclosporin, is disclosed herein. A composition comprising a therapeutically effective concentration of cyclosporin A and an effective amount of a vitamin E tocopherol polyethylene glycol succinate, wherein said composition is an aqueous liquid solution which is intended for parenteral use, and wherein no hydrophilic organic solvent is present at a mass concentration greater than or equal to that of the cyclosporin, is disclosed herein. Methods of treating diseases or conditions using said compositions, and medicaments related thereto, are also disclosed herein.
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