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发明申请
US20050287663A1 DNA encoding human alpha and beta subunits of neuronal nicotinic acetylcholine receptor, cells transformed therewith, and a recombinant cell line expressing a functional human alpha7 subunit of neuronal nicotinic acetylcholine receptor 审中-公开
编码神经元烟碱乙酰胆碱受体的人α和β亚基的DNA，用其转化的细胞和表达神经元烟碱乙酰胆碱受体的功能性人α7亚基的重组细胞系

DNA encoding human alpha and beta subunits of neuronal nicotinic acetylcholine receptor, cells transformed therewith, and a recombinant cell line expressing a functional human alpha7 subunit of neuronal nicotinic acetylcholine receptor
摘要：
Isolated nucleic acid molecules, i.e., DNA or RNA encoding human neuronal nicotinic acetylcholine receptor α and β subunits, mammalian and amphibian cells containing said DNA, methods for producing α and β subunits and recombinant (i.e., isolated or substantially pure) α subunits and β subunits are provided. In addition, cells expressing various multimeric combinations of subunits (i.e., α1, α2 α3 α4 α5 α6 and/or α7 in combination with at least one of an α and β subunit are also provided. A recombinant, non-human cell line expressing the human α7 subunit of nAChR is also disclosed.
摘要（中）：

分离的核酸分子，即编码人神经元烟碱乙酰胆碱受体α和β亚基的DNA或RNA，含有所述DNA的哺乳动物和两栖动物细胞，用于产生α和β亚基的方法和重组（即，分离或基本上纯的）α亚基和β 提供亚单位。 此外，表达亚基的各种多聚体组合的细胞（即α1，α2，α3，α4， 还提供了与α和β亚基中的至少一个组合的α5α6和/或α7，重组非 - 还公开了表达nAChR的人α7N亚基的人细胞系。

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