A system for imaging and treating a breast of a patient includes a table configured to receive the patient thereon, having an aperture formed therein configured to receive the breast of the patient pendent therethrough and positionable over a bath configured to contain a medium. Means for transmitting and receiving ultrasound signals is disposed in the bath. A frame is disposable out of the bath, and includes means for securing the breast to the frame to substantially maintain a position and a shape of the breast out of the bath as in the bath.