A method of transmitting a signal by using an Adaptive Modulation and Coding scheme in a Frequency Hopping-Orthogonal Frequency Division Multiplexing Access communication system capable of dividing total frequency bands into a plurality of sub-carrier bands and including a plurality of sub-channels, which are sets of predetermined sub-carrier bands, and a plurality of cells. The method includes the steps of allocating a predetermined number of sub-channels as AMC sub-channels per each cell matching with predetermined conditions in order to apply the AMC scheme to the AMC sub-channels, and allocating remaining sub-channels except for the AMC sub-channels as FH-OFDMA sub-channels in order to apply an FH-OFDMA scheme to the FH-OFDMA sub-channels.