- 专利标题: Gastrin releasing peptide compounds
-
申请号: US11165721申请日: 2005-06-24
-
公开(公告)号: US20060018830A1公开(公告)日: 2006-01-26
- 发明人: Enrico Cappelletti , Luciano Lattuada , Karen Linder , Edmund Marinelli , Palaniappa Nanjappan , Natarajan Raju , Kondareddiar Ramalingam , Rolf Swenson , Michael Tweedle
- 申请人: Enrico Cappelletti , Luciano Lattuada , Karen Linder , Edmund Marinelli , Palaniappa Nanjappan , Natarajan Raju , Kondareddiar Ramalingam , Rolf Swenson , Michael Tweedle
- 申请人地址: IT Milan
- 专利权人: Bracco Imaging S.p.A.
- 当前专利权人: Bracco Imaging S.p.A.
- 当前专利权人地址: IT Milan
- 主分类号: A61K51/00
- IPC分类号: A61K51/00 ; C07F5/00
摘要:
New and improved compounds for use in diagnostic imaging or therapy having the formula M-N—O—P-G, wherein M is a metal chelator having the structure: wherein R1-R5 and FG are as defined herein (in the form complexed with a metal radionuclide or not), N—O—P is the linker containing at least one non-alpha amino acid with a cyclic group, at least one substituted bile acid or at least one non-alpha amino acid, and G is the GRP receptor targeting peptide. In the preferred embodiment, M is an Aazta metal chelator or a derivative thereof. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.
公开/授权文献
- US07922998B2 Gastrin releasing peptide compounds 公开/授权日:2011-04-12