- 专利标题： Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane NMDA, 5HT3 and neuronal nicotinic receptor antagonists
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申请号： US11202115申请日： 2005-08-11
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公开(公告)号： US20060019983A1公开(公告)日： 2006-01-26
- 发明人: Christopher Parsons , Markus Henrich , Wojciech Danysz , Ivars Kalvinsh , Valerjans Kauss , Aigars Jirgensons , Markus Gold , Maksims Vanejevs
- 申请人： Christopher Parsons , Markus Henrich , Wojciech Danysz , Ivars Kalvinsh , Valerjans Kauss , Aigars Jirgensons , Markus Gold , Maksims Vanejevs
- 申请人地址： DE FRANKFURT
- 专利权人： MERZ PHARMA GMBH & CO. KGAA
- 当前专利权人： MERZ PHARMA GMBH & CO. KGAA
- 当前专利权人地址： DE FRANKFURT
- 主分类号： A61K31/46
- IPC分类号： A61K31/46 ; A61K31/403
摘要：
Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexanes which are systemically-active as NMDA, 5HT3, and nicotinic receptor antagonists, pharmaceutical compositions comprising the same, method of preparation thereof, and method of treating CNS disorders which involve disturbances of glutamatergic, serotoninergic, and nicotinic transmission, treating immunomodulatory disorders, and antimalaria, antitrypanosomal, anti-Borna virus, anti-HSV and anti-Hepatitis C virus activity.
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