发明申请
US20060024659A1 Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
审中-公开
膦酸酯核苷酸类似物的前体药物及其制备方法
- 专利标题： Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
- 专利标题（中）： 膦酸酯核苷酸类似物的前体药物及其制备方法
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申请号： US10785497申请日： 2004-02-24
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公开(公告)号： US20060024659A1公开(公告)日： 2006-02-02
- 发明人: Mark Becker , Harlan Chapman , Tomas Cihlar , Eugene Eisenberg , Gong-Xin He , Michael Kernan , William Lee , Ernest Prisbe , John Rohloff , Mark Sparacino
- 申请人： Mark Becker , Harlan Chapman , Tomas Cihlar , Eugene Eisenberg , Gong-Xin He , Michael Kernan , William Lee , Ernest Prisbe , John Rohloff , Mark Sparacino
- 专利权人： GILEAD SCIENCES, INC.
- 当前专利权人： GILEAD SCIENCES, INC.
- 主分类号： C12Q1/00
- IPC分类号： C12Q1/00 ; C12Q1/70
摘要：
A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.
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