- 专利标题： Compounds and methods for inhibiting the interaction of BCL proteins with binding partners
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申请号： US11156364申请日： 2005-06-17
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公开(公告)号： US20060025460A1公开(公告)日： 2006-02-02
- 发明人: Alfredo Castro , Wei Deng , Kristopher Depew , Michael Foley , Christian Fritz , Asimina Georges Evangelinos , Michael Grogan , Nafeeza Hafeez , Edward Holson , Brian Hopkins , Nii Koney , Tao Liu , David Mann , Lisa Marcaurelle , Daniel Snyder , Dennis Underwood , Andrew Wylie , Lin-Chen Yu , Linping Zhang
- 申请人： Alfredo Castro , Wei Deng , Kristopher Depew , Michael Foley , Christian Fritz , Asimina Georges Evangelinos , Michael Grogan , Nafeeza Hafeez , Edward Holson , Brian Hopkins , Nii Koney , Tao Liu , David Mann , Lisa Marcaurelle , Daniel Snyder , Dennis Underwood , Andrew Wylie , Lin-Chen Yu , Linping Zhang
- 申请人地址： US MA Cambridge
- 专利权人： Infinity Pharmaceuticals, Inc.
- 当前专利权人： Infinity Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Cambridge
- 主分类号： C07D261/02
- IPC分类号： C07D261/02 ; A61K31/42
摘要：
One aspect of the present invention relates to heterocyclic compounds that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising a heterocyclic compound of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer.