Methods and systems are provided for processing Card transactions. The Cards and Card Programs are configured on a Host System by a Client and transactions are received at a Host System. Issuers of Cards and their Program Groups are configured on the Host System. Acquirers of Card transactions and their Program Groups are configured on the Host System. An Issuer and Acquirer associated with singular Card transactions may or may not belong to the same Client. The Card transactions carry associated data relevant to the Card Type and transaction type captured and identified by the Host System for proper Transaction Set build and ultimate Card transaction processing based on the relevant Issuer and Acquirer set choices. A Web Interface is provided for Clients, their designees, and Cardholders.