Jokers 21 is a blend card game with the playing method of Casino War and Blackjack (twenty-one) that multiple players engage in taking turns to play their own hand against to dealer's hand. A method of playing Jokers 21 card game comprises a dealer and at least one player. It uses a shoe with six decks or eight decks of standard playing card with jokers (54 cards of each deck). In conjunction with standard rules of both Casino War and Blackjack card game, the jokers serve as a winning card. Any hand with a joker is automatically won. The Jokers 21 also allows players to wager on four different betting choices, One Card bet, One Card Tie bet, Jokers 21 bet, and Jokers 21 Tie bet.