A clock with luminous hands has a clock panel with a front clock surface and a rear surface to which a hand-driving assembly and a power inverter are mounted. The hand-driving assembly has a pin protruding through the clock panel and extending from the front clock surface. An hour hand and a minute hand both formed by single-pole CCFLs are mounted around the pin with one end. When the power inverter produces a high voltage conducting to the pin, both the hands are energized to generate light.