发明申请
US20060029546A1 Materials and methods for identifying anti-schizophrenic agents
审中-公开
识别抗精神分裂症药物的材料和方法
- 专利标题： Materials and methods for identifying anti-schizophrenic agents
- 专利标题（中）： 识别抗精神分裂症药物的材料和方法
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申请号： US10912971申请日： 2004-08-06
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公开(公告)号： US20060029546A1公开(公告)日： 2006-02-09
- 发明人: Mark Gurney , Sascha Haverfield-Gross , Thorkell Andressen , Maria Bjarnadottir
- 申请人： Mark Gurney , Sascha Haverfield-Gross , Thorkell Andressen , Maria Bjarnadottir
- 申请人地址： US IL Woodridge
- 专利权人： deCODE Genetics, Inc.
- 当前专利权人： deCODE Genetics, Inc.
- 当前专利权人地址： US IL Woodridge
- 主分类号： A61K49/00
- IPC分类号： A61K49/00 ; C12Q1/68
摘要：
The invention relates to materials and methods of identifying modulators of N-methyl-D-Aspartate (NMDA) receptor phosphorylation and function, including anti-schizophrenic agents that modulate NMDA receptor function. The methods of the invention utilize animal models of schizophrenia and cell-based assays to identify modulators of NMDA function. The invention further provides anti-schizophrenic agents identified by these methods. The invention relates to methods of treating schizophrenia using the modulators and anti-schizophrenic agents identified by the methods of the invention.
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