- 专利标题： Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor
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申请号： US11205341申请日： 2005-08-16
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公开(公告)号： US20060030735A1公开(公告)日： 2006-02-09
- 发明人: Benjamin Frydman , Linda Clifford , Aldonia Valasinas , Andrei Blokhin , Aparajita Sarkar , Hirak Basu , Venodhar Reddy , Laurence Marton , Yu Wang
- 申请人： Benjamin Frydman , Linda Clifford , Aldonia Valasinas , Andrei Blokhin , Aparajita Sarkar , Hirak Basu , Venodhar Reddy , Laurence Marton , Yu Wang
- 申请人地址： US CA Redwood City
- 专利权人： CellGate, Inc.
- 当前专利权人： CellGate, Inc.
- 当前专利权人地址： US CA Redwood City
- 主分类号： C07C211/34
- IPC分类号： C07C211/34
摘要：
Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearing or carbene equivalent-bearing compound is reacted with the double bond of an alkene compound to form a cyclopropyl ring as the first step in the synthesis.
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