Provided are a method, system, and program for distributing application transactions among work servers. Application transaction rates are determined for a plurality of applications supplying transactions to process. For each application, available partitions in at least one server are assigned to process the application transactions based on partition transaction rates of partitions in the servers. For each application, a determination is made of weights for each server including partitions assigned to the application based on a number of partitions in the server assigned to the application. The determined weights for each application are used to distribute application transactions among the servers including partitions assigned to the application.