发明申请
US20060035847A1 Glucopyranosyloxyprazole derivatives and use thereof in medicines
有权
吡喃葡萄糖基吡唑衍生物及其在药物中的应用
- 专利标题: Glucopyranosyloxyprazole derivatives and use thereof in medicines
- 专利标题(中): 吡喃葡萄糖基吡唑衍生物及其在药物中的应用
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申请号: US11247356申请日: 2005-10-12
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公开(公告)号: US20060035847A1公开(公告)日: 2006-02-16
- 发明人: Hideki Fujikura , Nobuhiko Fushimi , Toshihiro Nishimura , Takeshi Nakabayashi , Masayuki Isaji
- 申请人: Hideki Fujikura , Nobuhiko Fushimi , Toshihiro Nishimura , Takeshi Nakabayashi , Masayuki Isaji
- 专利权人: KISSEI PHARMACEUTICAL CO., LTD.
- 当前专利权人: KISSEI PHARMACEUTICAL CO., LTD.
- 优先权: JP403534/2000 20001228
- 主分类号: A61K31/7056
- IPC分类号: A61K31/7056 ; C07H17/02
摘要:
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R represents a hydrogen atom, a lower alkyl group or a group forming a prodrug; one of Q and T represents a group represented by the general formula: (wherein P represents a hydrogen atom or a group forming a prodrug), while the other represents a lower alkyl group or a halo(lower alkyl) group; R2 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a halo (lower alkyl) group or a halogen atom; and with the proviso that P does not represent a hydrogen atom when R represents a hydrogen atom or a lower alkyl group, or pharmaceutically acceptable salts thereof, which exert an inhibitory activity in human SGLT2 and have an improved oral absorption, and therefore are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, and pharmaceutically acceptable salts thereof, and pharmaceutical uses thereof.
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