发明申请
US20060035925A1 SUBSTITUTED 4H-CHROMENES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF
审中-公开
取代的4H-色素和模拟物作为病毒和杀虫剂的激活剂及其用途
- 专利标题： SUBSTITUTED 4H-CHROMENES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF
- 专利标题（中）： 取代的4H-色素和模拟物作为病毒和杀虫剂的激活剂及其用途
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申请号： US11150586申请日： 2005-06-13
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公开(公告)号： US20060035925A1公开(公告)日： 2006-02-16
- 发明人: Sui Cai , Hong Zhang , Songchun Jiang , Richard Storer
- 申请人： Sui Cai , Hong Zhang , Songchun Jiang , Richard Storer
- 申请人地址： US CA San Diego
- 专利权人： Cytovia, Inc.
- 当前专利权人： Cytovia, Inc.
- 当前专利权人地址： US CA San Diego
- 主分类号： A61K31/407
- IPC分类号： A61K31/407 ; A61K31/353
摘要：
The present invention is directed to substituted 4H-chromenes and analogs thereof, represented by the general Formula I: wherein R1-R5, A, Y and Z are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
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