An apparatus and method for changing an uplink power control scheme according to mobile status in a TDD mobile communication system are provided. A subscriber station transmits to a base station a power control change request message including information about a requested power control scheme. Upon receipt of the power control change request message, the base station selects a power control scheme for the uplink of the subscriber station and transmits to the subscriber station a power control change command message including information about the selected power control scheme. The subscriber station extracts, upon receipt of the power control change command message from the base station, the power control scheme information from the power control change command message and selects a power control scheme according to the extracted information.