A controller directs performance of a process having multiple process parameters (MPPs), including a controllable process parameter (CTPP), a targeted process parameter (TPP), a defined target value (DTV) representing a limit on an actual average value (AAV) of the TPP over a defined moving time period of length TPLAAV. A storage device stores historical data representing the AVs of the TPP at various times over a prior time period (PTP) having a length of at least TPLAAV. A processor predicts future average values (FAVs) of the TPP over a future time period (FTP) based on the stored historical data and the current values of the MPPs. The processor also determines a target set point for each CTPP based on the predicted FAVs, the current values of the MPPs and the DTV, and directs control of each CTPP in accordance with the determined target set point for that CTPP.