发明申请
US20060052385A1 8-Fluoroimidazo 1,2-a pyridine derivatives as ligands for gaba receptors
失效
8-氟咪唑并[1,2-a]吡啶衍生物作为gaba受体的配体
- 专利标题： 8-Fluoroimidazo 1,2-a pyridine derivatives as ligands for gaba receptors
- 专利标题（中）： 8-氟咪唑并[1,2-a]吡啶衍生物作为gaba受体的配体
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申请号： US10515165申请日： 2003-05-25
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公开(公告)号： US20060052385A1公开(公告)日： 2006-03-09
- 发明人: Wesley Blackaby , Jose Castro Pineiro , Simon Goodacre , David Hallett , Alexander Humphries , Philip Jones , Kevin Merchant , Michael Reader
- 申请人： Wesley Blackaby , Jose Castro Pineiro , Simon Goodacre , David Hallett , Alexander Humphries , Philip Jones , Kevin Merchant , Michael Reader
- 优先权： GB0212049.1 20020524
- 国际申请： PCT/GB03/02250 WO 20030525
- 主分类号： A61K31/506
- IPC分类号： A61K31/506 ; A61K31/502 ; A61K31/497 ; C07D471/02
摘要：
A class of 8-fluoroimidazo[1,2-α]pyridine derivatives, substituted at the 3-position by an optionally substituted five-membered or six-membered heteroaromatic ring, being selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 and/or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.