A combination structure node is provided by a graphical programming development environment for use in a graphical program, where the combination structure node is operable to perform two or more control flow functions. For example, the combination structure node may be operable to perform two or more of: iteration, looping, conditional branching, sequencing, timed execution, event-driven execution, or other control flow functions. A user may include the combination structure node in a graphical program and associate a graphical code portion with the combination structure node. During execution of the graphical program, the combination structure node is operable to cause the associated graphical code portion to execute according to the two or more control flow functions performed by the combination structure node.