Various embodiments of a biological interface system and their related methods are disclosed. A biological interface system may include a sensor including a plurality of electrodes configured to detect multicellular signals emanating from one or more living cells of a patient and a processing unit configured to receive the multicellular signals from the sensor, to process the multicellular signals to produce processed signals, and to transmit the processed signals. The system may also include a controlled device configured to receive the processed signals from the processing unit. The processing unit may include a processing unit first portion and a processing unit second portion, where the processing unit first portion is implanted under the scalp on the skull of the patient, and the processing unit second portion is placed above the scalp of the patient at a location proximal to the processing unit first portion.