A wireless communication interface for inertial measurement unit is disclosed. One or more instrumentation sensors, a processor, a wireless radio frequency transceiver with an antenna, and a power source are sealed within an inertial sensor assembly. The processor is adapted to receive output signals from the instrumentation sensors and to convert the output signals into a stream of digital data packets. A radio frequency transceiver is coupled to the processor and adapted to wirelessly communicate the stream of digital data packets through the antenna. In one embodiment, the radio frequency transceiver is further adapted to wirelessly receive a stream of digital data packets through the antenna and communicate the received digital data packets to the processor.