发明申请
- 专利标题: Formation of polyampholytes in the presence of a polyion
- 专利标题(中): 在聚阴离子存在下形成聚阴离子
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申请号: US11256322申请日: 2005-10-21
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公开(公告)号: US20060063257A1公开(公告)日: 2006-03-23
- 发明人: Darren Wakefield , David Rozema , Jon Wolff , Vladimir Trubetskoy , James Hagstrom , Vladimir Budker , Jason Klein , So Wong
- 申请人: Darren Wakefield , David Rozema , Jon Wolff , Vladimir Trubetskoy , James Hagstrom , Vladimir Budker , Jason Klein , So Wong
- 主分类号: C12N15/87
- IPC分类号: C12N15/87
摘要:
Polyampholyte are able to condense nucleic acid to form small complexes which can be utilized in the delivery of nucleic acid to mammalian cells. The polyampholytes can be formed prior to interaction with nucleic acid or they can be formed in the presence of nucleic acid. Stabilized polycation/nucleic acid complexes can be modified to reduce the positive charge of the polycation and add targeting ligands without destabilizing the complex. The resultant particles retain their small size and are more effective in delivery of nucleic acid to cells in vivo.
公开/授权文献
- US07470539B2 Formation of polyampholytes in the presence of a polyion 公开/授权日:2008-12-30