发明申请
US20060063721A1 AI-2 compounds and analogs based on salmonella typhimurium LsrB structure
失效
基于鼠伤寒沙门氏菌LsrB结构的AI-2化合物和类似物
- 专利标题： AI-2 compounds and analogs based on salmonella typhimurium LsrB structure
- 专利标题（中）： 基于鼠伤寒沙门氏菌LsrB结构的AI-2化合物和类似物
-
申请号： US11228707申请日： 2005-09-16
-
公开(公告)号： US20060063721A1公开(公告)日： 2006-03-23
- 发明人: Stephen Miller , Karina Xavier , Michiko Taga , Shawn Campagna , Martin Semmelhack , Bonnie Bassler , Frederick Hughson
- 申请人： Stephen Miller , Karina Xavier , Michiko Taga , Shawn Campagna , Martin Semmelhack , Bonnie Bassler , Frederick Hughson
- 主分类号： A61K31/70
- IPC分类号： A61K31/70 ; A61K31/4015 ; A61K31/381 ; A61K31/12
摘要：
This invention relates to crystals comprising apo-LsrB and holo-LsrB. The structure of holo-LsrB identifies a tetrahydroxytetrahydrofuran derived from 4,5-dihydroxy-2,3-pentanedione (DPD) as the active autoinducer-2 (AI-2) molecule in Salmonella typhimurium. The X-ray crystallographic data can be used in a drug discovery method. Additionally the invention provides AI-2 analogs based on this discovery as well as pharmaceutical compositions containing those analogs.
公开/授权文献
信息查询
