发明申请
US20060063943A1 Process for preparing optically active 3-(methylamino)-1-(2-thienyl) propan-1-ol and intermediates for preparation
失效
光学活性3-（甲基氨基）-1-（2-噻吩基）丙-1-醇的制备方法和制备中间体
- 专利标题： Process for preparing optically active 3-(methylamino)-1-(2-thienyl) propan-1-ol and intermediates for preparation
- 专利标题（中）： 光学活性3-（甲基氨基）-1-（2-噻吩基）丙-1-醇的制备方法和制备中间体
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申请号： US10947333申请日： 2004-09-23
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公开(公告)号： US20060063943A1公开(公告)日： 2006-03-23
- 发明人: Kenichi Sakai , Rumiko Sakurai , Atsushi Yuzawa , Kaoru Hatahira
- 申请人： Kenichi Sakai , Rumiko Sakurai , Atsushi Yuzawa , Kaoru Hatahira
- 主分类号： C07D333/12
- IPC分类号： C07D333/12
摘要：
Disclosed is a process for commercial preparation of 3-(methylamino)-1-(2-thienyl)propan-1-ol (hereinafter abbreviated as “MMAA”) of the formula below: The process is carried out by the diastereomeric salt formation method using optically active mandelic acid or its derivatives, or an optically active tartaric acid derivative as the resolving agent. The product compound, diastereomeric satls, is useful as the intermediate for producing pharmaceuticals, such as duloxetine.
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