A method and apparatus for managing cache injection in a multiprocessor system reduces processing time associated with direct memory access transfers in a symmetrical multiprocessor (SMP) or a non-uniform memory access (NUMA) multiprocessor environment. The method and apparatus either detect the target processor for DMA completion or direct processing of DMA completion to a particular processor, thereby enabling cache injection to a cache that is coupled with processor that executes the DMA completion routine processing the data injected into the cache. The target processor may be identified by determining the processor handling the interrupt that occurs on completion of the DMA transfer. Alternatively or in conjunction with target processor identification, an interrupt handler may queue a deferred procedure call to the target processor to process the transferred data. In NUMA multiprocessor systems, the completing processor/target memory is chosen for accessibility of the target memory to the processor and associated cache.