A body frame of a saddle-ride type vehicle for preventing an increase in the number of parts for supporting a radiator and ensuring a required heat dissipating performance of the radiator. A body frame includes a pair of right and left main pipes extending substantially in the back-and-forth direction of a vehicle with a pair of right and left lower pipes disposed under the main pipes and extending substantially in the back-and-forth direction of the vehicle. A pair of right and left down-pipes are disposed vertically in a bridgewise manner between the main pipes and the lower pipes with rear reinforcing pipes extending rearwardly and obliquely downwardly, respectively, from intermediate positions of the down-pipes and connected at lower ends thereof to the lower pipes. First reinforcing members are provided for supporting an upper portion of a radiator. Second reinforcing members are provided for supporting a lower portion of the radiator.