发明申请
- 专利标题: Soluble receptor BR43x2 and methods of using
- 专利标题(中): 可溶性受体BR43x2及其使用方法
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申请号: US11200992申请日: 2005-08-10
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公开(公告)号: US20060067933A1公开(公告)日: 2006-03-30
- 发明人: Jane Gross , Wenfeng Xu , Karen Madden , David Yee
- 申请人: Jane Gross , Wenfeng Xu , Karen Madden , David Yee
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; C07H21/04 ; C12P21/06 ; C07K14/72
摘要:
Soluble, secreted tumor necrosis factor receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise one cysteine-rich repeat that is homologous to other tumor necrosis factor receptors, such as transmembrane activator and CAML-interactor (TACI). The polypeptides may be used for detecting ligands, agonists and antagonists. The polypeptides may also be used in methods that modulate B cell activation.