A frequency domain representation of a whitening filter is made to depend on essentially one unknown, namely, a scaling factor that is based on an estimated ratio of total base station power to the power spectral density (PSD) of inter-cell interference plus noise. In turn, that scaling factor can be computed based on the modeling terms used in a parametric model of the impairment correlations for a received communication signal. Preferably, the model comprises an interference impairment term scaled by a first model fitting parameter, and a noise impairment term scaled by a second model fitting parameter. Further, the scaling factor can be computed by directly estimating total base station transmit power and the PSD of inter-cell interference plus noise. In any case, the whitening filter can be used in whitening a received communication signal in conjunction with channel equalization processing or RAKE receiver processing, for example.