- 专利标题: Multicyclic compounds which inhibit leukocyte adhesion mediated by VLA-4
-
申请号: US11285889申请日: 2005-11-22
-
公开(公告)号: US20060074110A1公开(公告)日: 2006-04-06
- 发明人: Francine Grant , Bradley Johnson , Michael Pleiss , Eugene Thorsett
- 申请人: Francine Grant , Bradley Johnson , Michael Pleiss , Eugene Thorsett
- 专利权人: Elan Pharmaceuticals, Inc.
- 当前专利权人: Elan Pharmaceuticals, Inc.
- 主分类号: A61K31/455
- IPC分类号: A61K31/455 ; A61K31/401 ; C07C237/24 ; A61K31/215
摘要:
Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.